Researchers in China have discovered a new bat coronavirus, HKU5-CoV-2, that may infect humans. Similar to SARS-CoV-2, it can bind to human ACE2 cells. Although it poses a potential risk for zoonotic spillover, experts believe that existing immunity in the population significantly reduces the likelihood of a new pandemic.
A recently identified bat coronavirus, HKU5-CoV-2, that poses a potential risk of infecting humans has been discovered in China. Led by renowned virologist Shi Zhengli, known as “Batwoman,” the research team at the Wuhan Institute uncovered that HKU5-CoV-2 shares similarities with SARS-CoV-2, the virus responsible for the COVID-19 pandemic. This new virus can interact with human ACE2 cells in a manner reminiscent of how SARS-CoV-2 operates.
HKU5-CoV-2 belongs to the merbecovirus subgenus, which includes viruses causing Middle East Respiratory Syndrome (MERS). The research indicated that HKU5-CoV-2 could successfully infect human cell cultures, utilizing mini-human organ models. The study highlights the importance of monitoring bat merbecoviruses due to their capacity for animal-to-human transmission, although the specific potential for this virus to spillover remains to be explored.
Further analysis revealed that HKU5-CoV-2 has a superior capacity to bind to human ACE2 compared to other related viruses. According to the researchers, “Authentic HKU5-CoV-2 infected human ACE2-expressing cell lines and human respiratory and enteric organoids.” This finding emphasizes the zoonotic risk posed by these viruses and suggests a need for ongoing vigilance.
When questioned about the threat of a new pandemic resulting from this discovery, Dr. Michael Osterholm, an expert in infectious diseases, deemed the concerns exaggerated. He pointed out that the population has developed significant immunity to SARS viruses since 2019, which may lead to a decreased risk of widespread infection. The researchers also noted that HKU5-CoV-2 has less binding affinity to human ACE2 compared to SARS-CoV-2, diminishing its immediate pandemic threat.
In summary, the discovery of HKU5-CoV-2, a new bat coronavirus capable of infecting humans, raises important questions about potential zoonotic transmissions. Although the study indicates a lower risk of emergence compared to SARS-CoV-2, ongoing monitoring and research are essential. Experts encourage a cautious yet measured response to this finding, underscoring the importance of existing immunity within the population.
Original Source: www.ndtv.com
